ReCARDO: Using Real-World Data to Derive Common Data Elements for Alzheimer’s Disease and AD-Related Dementias Research Through Ontological Innovation

NIA-U24AG098157

ReCARDO Investigators

Degui Zhi Dennis Lal Germán Villa Yonghui Wu Yong Chen

About Development of CDEs for AD/ADRD (AD-CDEs) cover seven designated domains Development, refinement, adoption of AD-CDEs through collaboration and validation Resource sharing and dissemination Administrative support key functions

Develop a federated data ecosystem infrastructure for AD-CDE-incorporated NIA-funded studies through CDE extraction (CDE-Data) leveraging advanced data science solutions and AI/ML/NLP techniques.
Operationalize CDE-Data for developing longitudinal study data sets from RWD and produce a comprehensive inventory of data sources for aging populations.
Develop objective evaluative frameworks to assess the readiness and fitness-for-purpose of RWD for clinical evidence generation.
Evaluate study feasibility, availability of data, readiness of the data, and reproducibility of CDE-incorporated studies within and beyond the RRN through a national pilot study program, leveraging innovation capacities offered by CDE-Engine and CDE-Data.